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バイオ 2021.12
Nakamura T et al. The Abundance of Anti-Galactose-deficient IgA1 Autoantibodies Results in Glomerular Deposition and IgA Nephropathy Recurrence after Renal Transplantation. Transplantation. 2021 Dec 1;105(12):e407-e408.
1. 高血圧・動脈硬化・循環器疾患関連 ヘルスケア 2021.11
Miki S et al. S-1-Propenylcysteine promotes IL-10-induced M2c macrophage polarization through prolonged activation of IL-10R/STAT3 signaling. Sci Rep. 2021 Nov 17;11(1):22469.
バイオ 2021.10
Nakamura T and Shirouzu T Antibody-Mediated Rejection and Recurrent Primary Disease: Two Main Obstacles in Abdominal Kidney, Liver, and Pancreas Transplants. J. Clin. Med. 2021, 10, 5417.
創薬 2021.10
Ricciardiello F et al. Poorly Differentiated Neuroendocrine Larynx Carcinoma: Clinical Features and miRNAs Signature—A New Goal for Early Diagnosis and Therapy? J. Clin. Med. 2021, 10, 2019.
バイオ 2021.09
Yanagawa S et al. Development of a humanized mouse model to analyze antibodies specific for human leukocyte antigen (HLA). PLoS ONE 16(2): e0236614.
バイオ 2021.08
Shimabukuro S et al. Improved detection of donor-specific HLA-class II antibody in kidney transplant recipients by modified immunocomplex capture fluorescence analysis. Transplant Immunology Volume 67, August 2021, 101418
8. 熟成ニンニク抽出液の構成成分と分析結果関連 ヘルスケア 2021.06
Abe K et al. Identification and Characterization of Sulfur Heterocyclic Compounds That Contribute to the Acidic Odor of Aged Garlic Extract. J. Agric. Food Chem. 2021, 69, 3, 1020–1026
6. 免疫機能関連 ヘルスケア 2021.06
鈴木順一朗 熟成ニンニク抽出液の免疫調整作用 FOOD Style 21. 2021;25(1):53-5.
1. 高血圧・動脈硬化・循環器疾患関連 ヘルスケア 2021.06
Kunimura K et al. S-1-propenylcysteine improves TNF-α-induced vascular endothelial barrier dysfunction by suppressing the GEF-H1/RhoA/Rac pathway. Cell Commun Signal. 2021; 19: 17.
創薬 2021.06
Takashima M et al. Localized and systemic inflammatory mediators in a murine acute mastitis model. Journal of Inflammation Research 2021:14 4053–4067.
創薬 2021.06
Kawasaki H and Amano H Anti-inflammatory role of microRNA-429 in human gingival epithelial cells – inhibition of IL-8 production through direct binding to IKKβ mRNA. MOLECULAR MEDICINE REPORTS 24: 581, 202
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Tsuneyoshi T et al. Dehydrodiconiferyl alcohol suppresses monocyte adhesion to endothelial cells by attenuation of JNK signaling pathway. Biochem Biophys Res Commun. 2015 Sep 25; 465(3): 408-13.
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Yamakawa T et al. Aged garlic extract and one of the constituent, (+)-(2S,3R)-Dehydrodiconiferyl alcohol, inhibits alkaline phosphatase activity induced by inflammation factors in human vascular smooth muscle cells. Food and Nutrition Science. 2014; 5(2): 177-184.
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Weiss N et al. Aged garlic extract restores nitric oxide bioavailability in cultured human endothelial cells even under conditions of homocysteine elevation. J Ethnopharmacol. 2013; 145(1): 162-7.
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Morihara N et al. Aged garlic extract inhibits homocysteine-induced scavenger receptor CD36 expression and oxidized low-density lipoprotein cholesterol uptake in human macrophages in vitro. J Ethnopharmacol. 2011; 134(3): 711-6.
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Morihara N et al. Aged garlic extract inhibits CD36 expression in human macrophages via modulation of the PPARgamma pathway. Phytother Res. 2010; 24(4): 602-8.
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Weiss N et al. Aged garlic extract improves homocysteine-induced endothelial dysfunction in macro-and microcirculation. J Nutr. 2006 Mar;136(3 Suppl):750S-754S.
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Ide N et al. Aged garlic extract inhibits homocysteine-induced CD36 expression and foam cell formation in human macrophages. J Nutr. 2006 Mar;136(3 Suppl):755S-758S.
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Morihara N et al. Aged garlic extract maintains cardiovascular homeostasis in mice and rats. J Nutr. 2006 Mar;136(3 Suppl):777S-781S.
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Morihara N et al. Aged garlic extract inhibits peroxynitrite-induced hemolysis. Redox Rep. 2005; 10(3): 159-65.
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Budoff MJ et al. Inhibiting progression of coronary calcification using Aged Garlic Extract in patients receiving statin therapy: a preliminary study. Prev Med. 2004; 39(5): 985-91.
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Morihara N et al. Aged garlic extract enhances production of nitric oxide. Life Sci. 2002; 71(5): 509-17.
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Ide N, Lau BH. Garlic compounds minimize intracellular oxidative stress and inhibit nuclear factor-kappa b activation. J Nutr. 2001; 131(3s): 1020S-6S.
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Ho SE et al. S-allyl cysteine reduces oxidant load in cells involved in the atherogenic process. Phytomedicine. 2001; 8(1): 39-46.
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Matsuura H. Saponins in garlic as modifiers of the risk of cardiovascular disease. J Nutr. 2001; 131(3s): 1000S-5S.
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Moriguchi T et al. The effects of aged garlic extract on lipid peroxidation and the deformability of erythrocytes. J Nutr. 2001; 131(3s): 1016S-9S.
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Ide N, Lau BH. Aged garlic extract attenuates intracellular oxidative stress. Phytomedicine. 1999; 6(2): 125-31.
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Ide N et al. Antioxidant effects of fructosyl arginine, a Maillard reaction product in aged garlic extract. J Nutr. Biochem. 1999; 10(6): 372-6.
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Ide N, Lau BH. S-allylcysteine attenuates oxidative stress in endothelial cells. Drug Dev Ind Pharm. 1999; 25(5): 619-24.
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住吉博道. にんにくの抗酸化作用、成人病予防食品の開発. 1999; 91-98. シーエムシー出版.
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Ide N et al. Aged garlic extract and its constituents inhibit Cu(2+)-induced oxidative modification of low density lipoprotein. Planta Med. 1997; 63(3): 263-4.
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Ide N, Lau BH. Garlic compounds protect vascular endothelial cells from oxidized low density lipoprotein-induced injury. J Pharm Pharmacol. 1997; 49(9): 908-11.
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山崎毅. にんにく製剤およびにんにく由来イオウ化合物の抗酸化能. 日薬理誌. 1997; 110: 138-141.
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Yamasaki T et al. Garlic compounds protect vascular endothelial cells from oxidized low density lipoprotein-induced injury. Phytother Res. 1994; 8: 408-12.
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Adachi Y et al. Bis(allixinato)oxovanadium(IV) complex is a potent antidiabetic agent: Studies on structure-activity relationship for a series of hydroxypyrone-vanadium complexes. J Med Chem. 2006 Jun 1;49(11):3251-6.
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Adachi Y et al. Improvement of diabetes, obesity and hypertension in type 2 diabetic KKAy mice by bis(allixinato)oxovanadium(IV) complex. Biochem Biophys Res Commun. 2006 Jul 7;345(3):945-50.
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Adachi Y et al. A highly potent insulin-mimetic zinc(II) complex a Zn(S2O2) coordination mode : Bis(1,6-dimethyl-3-hydroxy-5-methoxy-2-pentyl-1,4-dihydropyridine-4-thionato)zinc(II). Chemistry Letter. 2005; 34(5): 656-657.
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Adachi Y et al. A new insulin-mimetic bis(allixinato)zinc(II) complex: structure-activity relationship of zinc(II) complexes. J Biol Inorg Chem. 2004; 9(7): 885-93.
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Morihara N et al. Aged garlic extract scavenges superoxide radical. Plant Foods Hum Nutr. 2011; 66(1):17-21.
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Kohda K et al. Enhancing effect of aged garlic extract on induction of morphological differentiation with neurite outgrowth in NGF-Treated PC12 Cells. Pharmacol. Pharm. 2012; 3: 37-43.
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武田秀勝ほか. 学生の試験ストレスに対する熟成ニンニク抽出液（AGE）の効果. 北方産業衛生. 2011;48:15-20.
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Ito Y et al. Protective effect of S-allyl-L-cysteine, a garlic compound, on amyloid beta-protein-induced cell death in nerve growth factor-differentiated PC12 cells. Neurosci Res. 2003; 46(1):119-25.
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Moriguchi T, Saito H. Aged garlic extract as a neurotrophic and anti-aging agent. Piante Medicinali. 2002; 1(3):114-28.
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Nishiyama N et al. Ameliorative effect of S-allylcysteine, a major thioallyl constituent in aged garlic extract, on learning deficits in senescence-accelerated mice. J Nutr. 2001; 131(3s): 1093S-5S.
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Sumi S et al. Isolation and characterization of the genes up-regulated in isolated neurons by aged garlic extract (AGE). J Nutr. 2001; 131(3s): 1096S-9S.
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住吉博道. ニンニクが脳機能に及ぼす作用. Food Style21. 1999; 3: 36-40.
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Moriguchi T et al. Allixin, a phytoalexin produced by garlic, and its analogues as novel exogenous substances with neurotrophic activity. Life Sci. 1997;61(14): 1413-20.
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Moriguchi T et al. Anti-ageing effect of aged garlic extract in the inbred brain atrophy mouse model. Clin Exp Pharmacol Physiol. 1997; 24(3-4): 235-42.
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Moriguchi T et al. Prolongation of life span and improved learning in the senescence accelerated mouse produced by aged garlic extract. Biol Pharm Bull. 1994;17(12): 1589-94.
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Morihara N et al. Garlic as an anti-fatigue agent. Mol Nutr Food Res. 2007; 51(11): 1329-34.
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Morihara N et al. Aged garlic extract ameliorates physical fatigue. Biol Pharm Bull. 2006; 29(5): 962-6.
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